motor neurons of the somatic nervous system

Methodsįor this review, the literature search was based on PubMed using the Mesh terms 'Motor Neuron Disease',“Bulbo-Spinal Atrophy, X-Linked”, 'Muscular Atrophy, Spinal', 'Spinal Muscular Atrophies of Childhood', 'Autonomic Nervous System', 'Autonomic Dysreflexia', 'Autonomic Nervous System Diseases', 'Adrenergic Fibers', 'Parasympathetic Nervous System', 'Sympathetic Nervous System', 'Cholinergic Fibers'. In this review, we will focus on findings of dysautonomia in motor neuron diseases in general and in SMA, both in humans and in animal models. Finally, although expression of ANS occurs in primary motor disorders and sympathicomimetics may show benefit in motor performance 3, it was not until recently, that a anatomical intersection of those two neurological systems have been found 4. Recent evidences have led to believe that these conditions may have a wider range of involvement, also affecting the ANS 2. However, this well established knowledge has been challenged by new clinical and experimental data. Until recently, acquired and hereditary motor neuron diseases have been considered disorders clinically and pathologically limited to the motor neurons. The pathological involvement can be either central, involving structures as the intermediolateral (IML) column, the dorsal nucleus of the vagus and other brainstem nuclei, or peripheral postganglionic path 1.

Symptoms are wide-ranging and unspecific therefore these conditions are often misdiagnosed. Dysautonomia is a general term used to describe a failure of the ANS. Results: In the present review, we will discuss the neuropathological and clinical features of dysautonomia reported in motor neuron disease in humans and animal models.Ĭonclusion: The literature points to considering careful autonomic evaluation and management in patients with motor neuron disorders.Īutonomic nervous system (ANS) disorders are found either as a primary disease or in association with other nervous system disorders. Objective: Review the literature on autonomic findings in motor neuron diseases. Autonomic nervous system findings have been reported in animal models, adult and child motor neuron diseases. Nevertheless a wider expression of symptoms and signs point to a more multisystemic involvement. Av Venceslau Braz, 215, Botafogo, Rio de Janeiro, RJ 22290-160, Brazilīackground: Motor neuron disorders predominately result in progressive weakness.

Rua Bruno Lobo 50, Cidade Universitária, Rio de Janeiro, RJ 21941-912, BrazilĢSchool of Medicine, Federal University of Rio de Janeiro (UFRJ) Rua Bruno Lobo 50, Cidade Universitária, Rio de Janeiro, RJ 21044-020, BrazilģThe Institute of Neurology, Federal University of Rio de Janeiro (UFRJ). Autonomic nervous system dysfunction in motor neuron diseasesĪlexandra Prufer de Queiroz Campos Araujo 1*, Igor Prufer de Queiroz Campos Araujo 2, Abelardo de Queiroz Campos Araujo 3ġInstitute of Pediatrics, Federal University of Rio de Janeiro (UFRJ).

Motor neurons of the somatic nervous system